Biomechanical aspects of reinforced implant over-dentures: a systematic review

AbstractPurposeThe purpose of this systematic review was to investigate the effect of reinforcement on the mechanical behaviour of implant overdenture (IOD) bases and its cumulative biological effect on the underlying supporting structures (implants and the residual ridge).Material and methodsThe required documents were collected electronically from PubMed and Web of Science databases targeting papers published in English that focused on denture base reinforcement for IOD prostheses in order to recognize the principal outcomes of reinforcement on the mechanical and biological properties of overdentures. Such biological outcomes as: strains on implants, peri-implant bone loss, residual ridge resorption, and strain on the residual alveolar ridge.ResultsA total of 269 citations were identified. After excluding any repeated articles between databases and the application of exclusion and inclusion criteria, only 13 publications fulfilled the inclusion criteria. Three publications investigated the mechanical properties of fibre and/or metal-reinforced implant overdentures while another 3 articles investigated the effect of metal reinforcement on stress distribution and strains transmitted to the underlying implants. In addition, 3 in vitro studies investigated the effect of metal reinforcement on overdenture base strain and stresses. Stress distribution to the residual ridge and strain characteristics of the underlying tissues were investigated by 2 in vitro studies. Five clinical studies performed to assist the clinical and prosthetic maintenance of metal-reinforced IOD were included. Data concerning denture base fracture, relining, peri-implant bone loss, probing depth, and implant survival rates during the functional period were extracted and considered in order to evaluate the mechanical properties of the denture base, residual ridge resorption and implant preservation rates, respectively.ConclusionThe use of a denture base reinforcement can reduce the fracture incidence in IOD bases by enhancing their flexural properties and reducing the overdenture base deformation. Strains on the underlying supporting structures of overdenture prostheses including dental implants and the residual ridge can be decreased and evenly distributed using a metal reinforcement.</div

Knowledge and Attitudes of Medical and Health Science Students in the United Arab Emirates toward Genomic Medicine and Pharmacogenomics: A Cross-Sectional Study

Medical and health science students represent future health professionals, and their perceptions are essential to increasing awareness on genomic medicine and pharmacogenomics. Lack of education is one of the significant barriers that may affect health professional&rsquo;s ability to interpret and communicate pharmacogenomics information and results to their clients. Our aim was to assess medical and health science students&rsquo; knowledge, attitudes and perception for a better genomic medicine and pharmacogenomics practice in the United Arab Emirates (UAE). A cross-sectional study was conducted using a validated questionnaire distributed electronically to students recruited using random and snowball sampling methods. A total of 510 students consented and completed the questionnaire between December 2018 and October 2019. The mean knowledge score (SD) for students was 5.4 (&plusmn;2.7). There were significant differences in the levels of knowledge by the year of study of bachelor&rsquo;s degree students, the completion status of training or education in pharmacogenomics (PGX) or pharmacogenetics and the completion of an internship or study abroad program (p-values &lt; 0.05. The top two barriers that students identified in the implementation of genomic medicine and pharmacogenomics were lack of training or education (59.7%) and lack of clinical guidelines (58.7%). Concerns regarding confidentiality and discrimination were stated. The majority of medical and health science students had positive attitudes but only had a fair level of knowledge. Stakeholders in the UAE must strive to acquaint their students with up-to-date knowledge of genomic medicine and pharmacogenomics